Pleroo Research Consulting
Pleroo Research Consulting is a team of drug discovery and clinical development experts that bring together a blend of experimental, clinical pharmacology as well as modeling and simulation expertise.
What do we do
We create custom solutions in ADME, PKPD and clinical pharmacology with our strong technical and mathematical modeling expertise. We create a spectrum of solutions from experimental designs to PBPK based modeling and simulation addressing key challenges in discovery and clinical development.
Who benefits from us
Executive leadership who need to make decisions of high impact, ensure value creation of the clinical assets, compare with available therapeutic options, require an independent purview or conduct due diligence for licensing a clinical asset.
Team leaders and Directors of discovery or clinical programs who need to address specific technical challenges or decision making.
Innovation teams that require an integrated model informed approach to enable candidate selection, custom experimental designs in ADME and PKPD, optimal clinical trial designs etc.
Custom solutions to research challenges with a blend of experimental data and mathematical modeling expertise
Physiological Based Pharmacokinetic Model (PBPK)
Many research teams might overlook the need to understand human PK profiles early in their research or might find it challenging to implement.
"Take advantage of the integrated approach and flexibility, of our solutions."
Using a set of carefully executed physicochemical and in-vitro studies commonly performed during discovery stages, we create rugged mechanistic 'PBPK' models that allow to visualize and compare your prospective clinical candidates in various human virtual trial scenarios. Additional data including pre-clinical PK that arrive in course of time would enrich the model enhance the confidence and predictability, as we move on.
For a clinical development candidate there is a wealth of data already available.It's time to put it to right use.
"With the right model driven approach we help you make informed decisions that save time, effort, resources and reduce the uncertainty over future outcomes."
Harness our expertise in PBPK :
“Visualize what is ahead, opportunities and challenges alike.”
Get to see the human plasma and tissue profiles simulated over various dose and regimen scenarios.
Develop mechanistic PKPD models: enhance the scope by incorporating current understanding of dose response, either empirical or mechanistic.
Simulate for a virtual population of human subjects understanding the major sources and impact of variability.
Evaluate drug interactions
Create optimal trial designs
Plan combination trials
Optimize formulation research
Contact us to know more...
PBPK based solutions_Pleroo Research_mailer.pdfConsulting in Clinical development Translational Research
Experimental PK-PD and Translational Research
Experimental designs, monitoring and review
IND supporting package development
ADME, PK-PD support for new drug discovery programs
Custom reports in ADME and PK-PD
Early stage clinical pharmacology
Early concepts validation, re-purposing, 505 B(2) application
Clinical development designs
Regulatory engagements
Model driven solutions for strategic decision
Take forward your research programs with our custom modeling expertise, technical designs, analysis, review or monitoring of your research.
To know more in detail please go to the page Services
Contact Pleroo Research
We look forward to hear about your research needs. If you have a query or would like us to contact you please email us and we will get back to you promptly.
Email: info@plerooresearch.com
'Your partner in Innovation'
www. plerooresearch.com